All posts by U.S. Stem Cell, Inc

April 2016 Journal Club

Join us for journal club and partake in a discussion with Kristin Comella as she reviews a recently published article, “Adipose-derived Mesenchymal Stem Cells Are Phenotypically Superior for Regeneration in the Setting of Osteonecrosis of the Femoral Head.”

When: Tuesday, May 3rd, 2016

Time: 12:00 PM EDT

RSVP HERE

ABSTRACT

Bone marrow-derived mesenchymal stem cells (bmMSCs) have been used as a cellular therapeutic option for treatment of osteonecrosis of the femoral head. However, use of bmMSCs as a treatment adjuvant for orthopedic disorders in general has achieved limited success. Adipose-derived MSCs (aMSCs) may be a more- efficient regenerative cell source given their greater quantity and protection from physiologic stress.

ABOUT KRISTIN COMELLA, MS

Ms. Comella is a world renowned expert on regenerative medicine with a focus on adipose derived stem cells. She was named number 24 on Terrapin’s list of the Top 50 Global Stem Cell Influencers and number 1 on the Academy of Regenerative Practices list of Top 10 Stem Cell Innovators. Ms. Comella has pioneered stem cell therapies from various sources including cord blood, bone marrow, muscle, and adipose. She led the team that gained the first ever FDA approval for a clinical trial using a combined cell and gene therapy product in the heart. In addition to advanced cell culturing experience, Ms. Comella’s repertoire includes managing the development, manufacturing, and quality systems of cellular products. She has developed a wide range of regenerative techniques and products that have now been successfully implemented into the clinic setting. She is currently serving as the Chief Scientific Officer and board member of US Stem Cell, a publically traded company focusing on the discovery, development, and commercialization of autologous cell therapies for the treatment of degenerative diseases.

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CEO’s Blog: April 2016

Dear shareholders and friends,

U.S. Stem Cell Inc. continues to innovate and grow, making our mark in the regenerative medicine field by developing a number of therapies and products for patients suffering from degenerative conditions. Our three main operating divisions (U.S. Stem Cell Training, VetBiologics, and U.S. Stem Cell Clinic), focus on the development and commercialization of cell-based therapies that repair and replace damaged tissues, cells, and organs, restoring them to their normal functions.

Because of our dedication to the field, we have been able to help patients who previously had very few options available to them. We have had success helping patients with degenerative conditions, markedly demonstrated in our Traumatic Brain Injury patients who’ve shown great results.  We have not only been able to treat thousands of patients, but also have been actively involved in training physicians in our field, and have made meaningful contributions to international guidelines for stem cell research.

All of this would not be possible without our shareholders, partners, and dedicated team of practitioners. I would like to personally thank you all for your invaluable contributions and on-going support.

This month, we are pleased to announce a number of new developments.

We have recently launched our brand new website, which we hope will clearly guide you through the work that we do. This is part of our dedication to keeping you fully informed about our business operations and our continuing innovations in the field of stem cell research. Navigate through to learn about our products, board members, company news, financial summaries, and much more.

Our business strives to make its operations as efficient and cost effective as possible. In the most recent quarter, our company has succeeded in reducing its expenditures in operational activities, general and administrative tasks, and marketing strategies. An increase in banking services has meant that our Gross Margin from 2014 and 2015 has decreased. Despite this fact, we have seen a growth in revenue, as well as an improvement in our capital deficit, net loss, and current liabilities.

A summary of U.S. Stem Cell’s most recent financial figures through 4th quarter 2015:

Reductions in expenditure

  • Cash used in Q4 2015 down 85% or $306K.
    • From $361K in Q4 2014 to $55K in Q4 2015
  • Cash used in operating activities down $255k or 24%.
    • From $1.1M in 2014 to $845k in 2015
  • Marketing, general, and administrative expenses down $1.4M or 28.9%
    • From $4.7M in 2014 to $3.3M in 2015

General improvements

  • Current liabilities down by $3.1 million or 28%
    • From $11.1M in 2014 to $8.0M in 2015
  • Working capital deficit improved by $4.4 million or 40%
    • From $10,957,443 in 2014 to $6,583,569 in 2015

Profits and losses

  • Revenue up by 8%
    • From $2.06M in 2014 to $2.2M in 2015
  • Net loss improved 26% from $2.3M in 2014 to $1.7M in 2015
    • Gain on debt in 2014 of $2.5M, compared to gain of debt of $2.6M in 2015
  • Gross Margin down from 58.9% in 2014 to 32.9% in 2015, primarily due to increase in banking service

We invite you to follow us on social media for the latest updates and information about U.S. Stem Cell.

Warm Regards,

Mike Tomas

President & CEO

 

The information provided above is not be relied upon for the purchase or sale of our securities.  Please see our filings with the Securities and Exchange Commission (found at sec.gov).  In addition, this release is for informational purposes only and is not an offer to purchase or sell any of our securities. Except for historical matters contained herein, statements made in this press release are forward-looking statements. Without limiting the generality of the foregoing, words such as “may”, “will”, “to”, “plan”, “expect”, “believe”, “anticipate”, “intend”, “could”, “would”, “estimate”, or “continue”, or the negative other variations thereof or comparable terminology are intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Also, forward-looking statements represent our management’s beliefs and assumptions only as of the date hereof. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if new information becomes available in the future. The Company is subject to the risks and uncertainties described in its filings with the Securities and Exchange Commission, including the section entitled “Risk Factors” in its Annual Report on Form 10-K for the year ended December 31, 2015, and its Quarterly Reports on Form 10-Q.

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CSO Kristin Comella Publishes Paper on the Integration of Stem Cells to Chondrocyte Derived Cartilage

Sunrise, FL – February 17, 2016 – US STEM CELL, Inc. (OTCQB:USRM) – The Chief Science Officer of US Stem Cell Inc, Kristin Comella, and a team of researchers from Florida International University and Mississippi State University published a paper in Plos One Journal. The team investigated the effectiveness of integrating tissue engineered cartilage derived from human bone marrow derived stem cells (HBMSCs) to healthy as well as osteoarthritic cartilage mimics using hydroxyapatite (HA) nanoparticles immersed within a hydrogel substrate. Assessment of explanted rabbit knees by histology demonstrated that cellularity within the repair tissues that had filled the defects were of significantly higher number (p < 0.05) when HA was used.

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Dr. William P. Murphy delivers Keynote Address at the Academy of Regenerative Practices

Sunrise, FL – February 9, 2016 – US STEM CELL, Inc. (OTCQB:USRM) – The chairman of the board of directors of US Stem Cell Inc, Dr. William P. Murphy, Jr., delivered the keynote address at the 2nd annual Academy of Regenerative Practices (www.regenerativeacademy.com) in Ft. Lauderdale, Florida this past weekend. A medical pioneer and founder of Cordis Corporation (now a Johnson & Johnson company), Dr Murphy is a medical doctor and inventor of medical devices including collaborating on a flexible sealed blood bag used for blood transfusions as well as patents for inventing the physiologic pace maker and the artificial kidney. He is the son of the American physician William Parry Murphy who shared the Nobel Prize in Physiology for Medicine in 1934, and Harriett Adams, the first licensed female dentist in Massachusetts.

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U.S. Stem Cell Now Trading USRM; Completes Financing Transaction

Sunrise, FL – December 4, 2015 – US STEM CELL, Inc. (OTC: USRM) (f/k/a Bioheart, Inc.) a Florida corporation, a leader in the regenerative medicine, cellular therapy industry providing physician based stem cell therapies to human and animal patients as well as a developer of novel autologous cell therapies, is pleased to announce the completion of its name change with its new trading symbol – USRM. Additionally, the Company has completed a financing transaction with Magna Equities II, LLC (“Magna”).

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U.S. Stem Cell Announces Positive Results for Traumatic Brain Injury (TBI) Patients

Sunrise, FL – December 3, 2015 – U.S. STEM CELL, Inc. (OTC: USRM), a Florida corporation, a leader in the regenerative medicine/cellular therapy industry, developer of novel autologous cell therapies, and provider of physician based stem cell therapies to human and animal patients, is pleased to announce that it has successfully completed five physician based treatments of traumatic brain injury (TBI) patients. The five patients, who received stromal vascular fraction from adipose tissue delivered intrathecally, have been treated over the past 12 months at the US Stem Cell Clinic located in Sunrise, FL

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U.S. Stem Cell, Inc. Reports Positive Results for 3Q 2015

Sunrise, FL – November 5, 2015 – U.S. STEM CELL, Inc., a Florida corporation, (f/k/a/ Bioheart, Inc.) a leader in the regenerative medicine, cellular therapy industry providing physician based stem cell therapies to human and animal patients as well as a developer of novel autologous cell therapies, is pleased to highlight the following results from operations for the quarter ending September 30, 2015:

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U.S. Stem Cell, Inc. (f/k/a/ Bioheart, Inc.) Receives FINRA Approval for Reverse Split and Name Change

Sunrise, FL – November 4, 2015 – U.S. STEM CELL, Inc., a Florida corporation, (f/k/a/ Bioheart, Inc.) a leader in the regenerative medicine, cellular therapy industry providing physician based stem cell therapies to human and animal patients as well as a developer of novel autologous cell therapies, is pleased to announce that it has received approval, effective today, from the Financial Industry Regulatory Authority (“FINRA”) to implement a reverse stock split in the ratio of 1 share for every 1,000 shares of its Common Stock. In connection with the Company’s reverse stock split, FINRA has assigned the Company a new stock symbol, BHRTD. The Company’s stock will be quoted as BHRTD through December 2, 2015, and thereafter, the trading symbol will be USRM (OTC Markets), reflecting the new name of the Company. The new CUSIP number is 90350U100. Additional information on the above transaction and name change can be found in our November 4, 2015 Form 8-K filing. Current stock certificates may be exchanged for new certificates by contacting the Company’s transfer agent, Continental Stock Transfer & Trust Company at:

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US STEM CELL (Bioheart) Announces Insiders Intend to Purchase Company Common Stock in the Open Market

SUNRISE, FL / ACCESSWIRE / September 17, 2015 / US STEM CELL, Inc. (in transition from Bioheart, Inc. (BHRT.OB)) – announces today that “insiders” led by Dr. William P. Murphy, Jr., Chairman and Mike Tomas, President and CEO, intend to purchase, in the open market, up to 5% of the issued and outstanding Common Stock of the Company. The planned insider purchases are subject to customary restrictions based upon any of the participant’s knowledge of material non-public information and are further subject to federal securities disclosure rules. As the planed insider purchases are to be executed by individuals, US STEM CELL cannot guarantee the number of shares to be purchased or the time frame in which these shares will be bought in the open market.

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For Immediate Release: Bioheart and Ascyrus Medical Execute Investment Agreement

Sunrise, FL – March 19, 2015 – Bioheart, Inc., a Florida Corporation (BHRT.OB) and Ascyrus Medical, LLC, a Florida Limited Liability Corporation are pleased to announce that they have entered into an investment agreement. The investment agreement provides for Bioheart to obtain a consolidating ownership stake in Ascyrus Medical upon the achievement of certain business milestones. Bioheart has through June 30, 2015 to meet its milestone obligations.

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For Immediate Release: Bioheart Touts 2014 Accomplishments; Seeks More in 2015

Sunrise, FL – March 17, 2015 – Bioheart, Inc., a Florida Corporation (BHRT.OB),an emerging enterprise in the regenerative medicine / cellular therapy industry is pleased to announce, following the release of its Form 10-K Annual Report, key 2014 accomplishments including but not limited to:

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For Immediate Release: Bioheart Strengthens Management Team with Appointment of Martin E. Schmieg as President of Vetbiologics, Inc.

Sunrise, FL – January 29, 2015 – Bioheart, Inc., a Florida Corporation (BHRT.OB), an emerging enterprise in the regenerative medicine / cellular therapy industry announced today the appointment of Martin E. Schmieg as President of Vetbiologics, Inc., the Company’s wholly owned animal health subsidiary.

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